Using single-molecule optical and AFM imaging and force-spectroscopy techniques, we seek to unravel the mechanistic components of the structure and dynamics of chromosomes. Our research interests involve:
It had been only in the nineties though, when nanotechnology had Highly developed into a amount exactly where one molecules might be manipulated, that the main experimental gadgets started to look.
Dynamics of initiation, termination and reinitiation of DNA translocation by the motor protein EcoR124I
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
This yielded a breakthrough. In just just a few months, we were being capable to measure transport through someone single-walled carbon nanotube. Determined by low-temperature experiments by an excellent PhD student in my team, Sander Tans (now a valued colleague and professor at Delft University of Know-how with an Energetic research lab at AMOLF in Amsterdam), we showed that carbon nanotubes were being real quantum wires with incredibly lengthy (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
MATLAB codes for facts processing can be obtained at . Julia codes used for numerical simulation are offered at .
Atomic drive microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in the cooperative manner
‘You should not just consider the queries of tomorrow, but in addition take into account the inquiries on the working day immediately after tomorrow’
‘The fantastically subtle way in which features in mother nature operate in no way ceases to amaze me. If we resolve the puzzle of how life arrived into being, I hope that my amazement for the complexity of development may have increased and with it my awe with the greatness on the Creator.’
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2001, discovery of one-electron transistors at room temperature according to nanotubes; realization of very first logic circuits with carbon nanotube gadgets; and discovery in the molecular framework of DNA mend enzymes with AFM
Visualization of unstained DNA nanostructures with Innovative in-concentrate transmission electron microscopy tactics
The biophysicist from Delft – who has become The most cited researchers within the Netherlands for years – takes his obligation to lead for the explanation and popularisation of his do the job within the border of physics and biology particularly significantly and frequently seems from the media; Otherwise to talk about his perform, then about the connection involving science and his Christian faith.